10 Months On Resveratrol & A New Human Study is Released!

I know, I know... I promised I would get updated blood work done in January.  The good news is I picked up the prescription form from my doctor, the bad news is I just haven't had a chance to make it to the lab.  With a newborn at home time has been a commodity I've had little of.

I will make it a point (pun intended) to get the blood test completed over the next week or two and post my results on my Cholesterol Page.  I will also be getting my body fat tested in the coming weeks as well.

Since starting the Nitro 250 Resveratrol two months ago I haven't noticed any additional changes other then some weight loss that may or may not be directly related to the resveratrol.  I have maintained  the same diet and exercise routine so there are possibilities the Nitro 250 has helped in regards to weight loss.  I am interested to see the results of my body fat analysis to compare it with previous tests.

The tricky part about analyzing whether resveratrol works or not is that if it is working, it may not be something you can feel.  If your cells are "more" healthy is that something you will notice?  It seems to me the only way to notice definitive, non anecdotal, changes would be with cellular testing, or living to be 120!  Perhaps the scientists studying resveratrol will come up with accurate ways of measuring the benefits and any potential side effects.

New Human Study Released:  Pharmacokinetic and Safety of Trans-Resveratrol in a Rising Multiple-Dose Study in Healthy Volunteers.

Mol Nutr Food Res. 2009 Feb 4th
 
Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers.

Almeida L, Vaz-da-Silva M, Falcão A, Soares E, Costa R, Loureiro AI, Fernandes-Lopes C, Rocha JF, Nunes T, Wright L, Soares-da-Silva P.

Department of Research and Development, BIAL - Portela & Co SA, S Mamede do Coronado, Portugal. Fax: +351-22-9866192.

This was a double-blind, randomized, placebo-controlled study to investigate the pharmacokinetics and safety of trans-resveratrol. In four groups of ten healthy adult subjects (five males and five females), two subjects were randomized to receive placebo and eight subjects to receive trans-resveratrol 25, 50, 100 or 150 mg, six times/day, for thirteen doses. Peak plasma concentrations of trans-resveratrol were reached at 0.8-1.5 h postdose. Following the 13th dose of trans-resveratrol 25, 50, 100 and 150 mg, mean peak plasma concentration (C(max)) was 3.89, 7.39, 23.1 and 63.8 ng/mL and mean area under the plasma concentration-time curve (AUC(0-tau)) was 3.1, 11.2, 33.0 and 78.9 ng.h/mL. Interindividual variability was high, with coefficients of variation >40%. Trans-resveratrol half-life was 1-3 h following single-doses and 2-5 h following repeated dosing. Trough (C(min)) concentrations were less, not double equals 1 ng/mL following 25 and 50 mg, 3 ng/mL following 100 mg and < 10 ng/mL following 150 mg. Trans-resveratrol pharmacokinetics showed circadian variation. Adverse events were mild in severity and similar between all groups. In conclusion, repeated administration was well-tolerated but produced relatively low plasma concentrations of trans-resveratrol, despite the high doses and short dosing interval used. Bioavailability was higher after morning administration.

PMID: 19194969

I do not have a subscription to the site providing this study so I am unable to get the particulars.  It is unknown the type of resveratrol used, the purity, or the delivery method.  If we assume it was 99% resveratrol not mixed and taken orally we get confirmation of it's low bioavailability in our blood plasma.

The study was on the smaller side with only 10 members, however, they conclude by stating resveratrol was "well tolerated" and was shown to have a higher bioavailability when consumed in the morning hours.  To my knowledge this is new information and I would be interested in seeing a follow up study completed.

Again, this brings up several more questions related to the best delivery method for resveratrol.  Is buccal delivery best?  How about trans-dermal delivery?  Or is mixing with other substances such as lecithin, Tween 80, alcohol, grape juice, or quercetin the best ways to increase bioavailability in humans?

These questions amongst many others about side-effects are what we want answered.  We will have to remain patient and hope more human studies are completed and released in the near future.

How do you take your resveratrol?  Do you mix it with anything or take it straight?  Let's discuss this and see what works best from a non-scientific point-of-view.  Please comment below!

Resveratrol Related Web Search

Comments

[Admin]

**Correction**

It has been brought to my attention the study included 40 people split into 4 groups of 10. Each group was administered a different amount of the resveratrol and 2 people from each group were randomly chosen as placebo participants.

[Worried]

The Tween family of emulsifiers include suspected carcingogens. I would be very careful about using Tween 80 in any form. It would be quite sad to take resveratrol with the intention of prolonging your life and improving health and supplementing it with a carcinogen.

[mike]

I've been taking it via buccal delivery

[Admin]

Mike,

If you have a moment could you explain what process you use in taking resveratrol by buccal delivery? I get a lot of questions about this method but have not tried it myself yet.

[john henthorne]

I think Resveratrol is great it just may be the fountain of youth maybe that is why the drug companys are trying to get there hands on it so they can make millions on a natural product