In the anti-ageing research world, there is a quiet but albeit, an important battle brewing. The battle is over whether or not resveratrol and compounds similar to it, such as SRT1720, actually do directly activate SiRT1.
The implications of such findings would have a great impact on companies developing anti-aging drugs or therapies associated with the SiRT1 gene. It will be interesting to see where the research takes us.
I have gathered some links for those of you interested in reading more on the topic:
SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1.
Faculty of 1000 Biology: evaluations for Pacholec M et al J Biol Chem 2010 Mar 12 285 (11) :8340-51
Nature News: Published online 24 March 2010 | Nature 464, 480-481 (2010) | doi:10.1038/464480a
Questions Rise Over Anti-Aging Drugs
Doubts grow over resveratrol and other compounds under development at the GSK company.
Technology Review, Published by MIT Author: Emily Singer
Just one reflexion about the resveratrol not being an activator of SIRT1, according to those findings resveratrol doesn't activate SIRT1 AND SIRT1 doesn't seem to prolong life anyway, I think the important thing to consider here is the original research showing that resveratrol prolonged the life about 30% in at least worms, yeast and mice, I may understand that a lab or labs got wrong about HOW resveratrol did this, but I don't think that Dr. Sinclair and others didn't know how to split a population of mice, worms, etc. in two groups and feed one group with regular nutrients as control group AND THE OTHER GROUP fed with the same nutrients PLUS resveratrol and observe whether the later group lives longer than the control group!.
In my case I will keep taking resveratrol as I have done since last three years, I would really like to hear your opinion on this.
Regards and thanks in advance.
Posted by: Felipe Rodriguez | September 25, 2011 at 07:26 PM